Hollywood will never be the same.

Legendary screenwriter Nora Ephron passed away Tuesday at the age of 71 after a long battle with leukemia, The New York Times reports.

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Over the course of her nearly four decades-long career as a screenwriter, Ephron penned numerous beloved films, including When Harry Met Sally and Sleepless in Seattle. She was a three-time Academy Award nominee for her original screenplays; in the early aughts, she took on writing for the stage. (In 2009, she coauthored the ensemble show Love, Loss, and What I Wore with sister Delia, also a screenwriter). Her 2010 collection of essays, I Feel Bad ABout My Neck: And Other Reflections on Being a Woman, was number one on The New York Times' best-siller list.

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Ephron's first marriage to writer Dan Greenburg ended in divorce in 1976. Later that same year, she married famed Watergate journalist Carl Bernstein, though the pair split bitterly in 1980. Seven years later, Ephron tied the knot for the third time with screenwriter Nicholas Pileggi.

After the filmmaker's health took a turn for the worse Tuesday, Deadline reported that Ephron had kept her illness a secret from fans and colleagues, and "wanted it to remain a private matter."

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Earlier this week, Ephron's longtime friend Liz Smith eulogized the writer in a touching essay.

"She was the Untouchable, the Meryl Streep of our writing times, a peer to glance upwards at while you pretended to be her equal," Smith wrote.